Suggested Use: Adults, take three (3) vegetable capsules with or at the end of each meal.
90 Vegetarian Capsules • Dietary Supplement
Keep Out of Reach of Children. Do not use if safety seal on cap or printed inner seal is missing or broken. Consult a physician if pregnant, lactating, currently on prescription medication or diagnosed with a medical condition. Store in a Cool, Dry Place.
Allergy Information: product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish and shellfish.
Dietary supplement FREE of milk, soy, salt, sugar, wheat, yeast, gluten, artificial flavors or preservatives.
Manufactured for and Distributed by: Emerald Labs, Carson, CA
Coenzymated Methyl Folate and the MTHFR Gene
Over 46% of Americans are born with one of several possible genetic mutations affecting either one MTHFR gene (heterozygous mutation) or both MTHFR genes (homozygous mutation).†*
If you happen to fall into either of these categories, YOUR HEALTH COULD BE AT SERIOUS RISK!
Natural folate can be found in foods such as leafy greens while supplements on the market may contain B9 as standard folic acid or as natural folate. Nonetheless, the body must convert either of these forms into its Coenzymated (6S)-5-Methyltetrahydrofolate MTHF active form in order for it to be effectively utilized.*
Who is at Risk?
In the United States alone, approximately 47% of Caucasians inherit the normal MTHFR 677CC gene, 42% inherit the weaker CT variant of the gene and about 11% inherit the much weaker TT variant. African-Americans fare better with approximately 78% inheriting the normal MTHFR 677CC gene, 20% inheriting the weaker CT variant, and only about 2% inheriting the much weaker TT variant.
Americans of Latin descent are more likely toinherit the less efficient variations of the MTHFR gene with only 35% that inherit the normal (677CC) gene, whereas 47% inherit the weaker CT variant and about 18% inherit the much weaker TT variant. (Thepercentages are extrapolations based on the testing of infants.) *†
Understanding How The MTHFR Gene Is Important
Our genes naturally code for, or program, the creation of tens of thousands of proteins and enzymes — basically telling each of our 70 trillion cells what to do. The MTHFR gene specifically codes for an enzyme called methylenetetrahydrofolate reductase. This enzyme (also known as MTHFR) depends on folate and also influences folic acid or natural folate activity in the body significantly.*
Every one of us is born carrying two MTHFR genes, one inherited from each of our parents.
About half of us inherit two fully functional versions of this gene, commonly known as MTHFR 677CC. This enzyme plays a crucial role in a series of bio-chemical reactions called methylation, which yield some of the most fundamental molecules in our bodies. For example, they produce the bio-chemical building blocks for mood-enhancing phospholipids and neuro- transmitters, such as serotonin. They’re also involved in repairing damaged genes and regulating how they function. If you have only this healthy version of the gene, when you consume the recommended daily amount of folate (400 mcg) from food or supplementation, the enzyme functions normally.*
“Most supplements available today do NOT contain the activated Coenzymated (6S)-5-Methyltetrahydrofolate MTHF form of natural folate. It was very important that we formulated using only this pure, activated form of Coenzymated Folate. By using only the pure, Coenzymated (6S)-5-Methyltetrahydrofolate MTHF form in our formulas, Emerald Labs offers optimal bioavail- ability toall, including those who are at risk.”
Rick Simpson, C.E.O. Emerald Labs
CT Gene Variation – Weaker
One such variation is known as MTHFR 677CT (heterozygous). This particular gene variation offers significantly reduced enzymatic activity, functioning at only 71% of normal, according to some estim- ates. This, in turn, compromises your body’s ability to produce essential biochemical building blocks, leaving you at a distinct disadvantage.* One of the consequences of the CT gene variation is that blood levels of homocysteine tend to be abnormally high.*† Too much homocysteine damages blood vessels and is a recognized risk factor for premature heart attack and stroke. Methylated Folate works in tandem with other B Vitamins, particularly B12 in its activated form, Methylcobalamin, to help deconstruct homocysteine. *
Studies indicate that high homocysteine levels resulting from an MTHFR gene variation may be a contributing factor for sufferers of chronic migraine headaches. Research also shows as strong connection between high homocysteine and an increased risk for the development of dementia and Alzheimer Disease later in life.*
TT Gene Variation – Much Weaker
As problematic as the CT version of the gene may seem, some people inherit an even more dangerous variation, known as MTHFR 677TT (homozygous). If you happen to be one of these people, your MTHFR enzymatic activity will only reach 34% of normal, according to some estimates. Your blood homocysteine level is likely to be very high, creating an even more significant cardiovascular and cognitive risk. This variation is also associated with a 69% greater risk of suffering from depression and a 36% higher risk of developing schizophrenia.*
Did you know?
Folate is essential in early fetal development, and a woman in her child-bearing years with an MTHFR gene mutation has a significantly greater risk of having a baby born with a neural-tube defect (NTD), such as spina bifida.†*
i. Crider KS, Zhu JH, Hao L, et al. MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr, 2011 Apr 20. [Epub ahead of print].
ii. Wilcken B, Bamforth F, Li Z, et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet, 2003;40:619-625.
iii Nat Rev Nerosci. 2006 September ; 7(9): 724-731. doi: 10.1038/nrn1986.
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent disease.